Turning Cold Tumors Hot: The RANK Pathway as an Immune Modulator in Breast Cancer

Posted in Research Summary

Although immune checkpoint inhibitors have changed the treatment landscape for some cancers such as melanoma and non-small cell lung cancer, other tumor types often described as immunologically “cold” do not respond well to immunotherapy. Using Bio X Cell’s Anti-mouse RANKL (clone IK22/5) antibody, researchers demonstrated that inhibition of the RANK pathway turns cold breast tumors into hot tumors that can potentially benefit from immunotherapy.
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Mucosal Microenvironment Matters: A Role for Neutrophilic Inflammation in Viral Predisposition

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Why do certain people become sick after exposure to a virus while others do not? Bio X Cell’s anti-mouse Ly6G (clone 1A8) and anti-mouse CD8 (clone YTS169.4) antibodies were used to help define neutrophilic inflammation as an important component of susceptibility to respiratory infections.
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Macrophages on the Move: Visualization of Patrolling Alveolar Macrophages

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More than 10,000 liters of non-sterile air pass through our lungs each day. Although most pathogens are filtered out in the upper respiratory tract, evidence suggests that some bacteria make their way into the alveoli where oxygen and carbon dioxide are exchanged in the lungs.
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The Gut Microbiome Links Stress to Sickle Cell Crisis

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Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in the hemoglobin gene. Hemoglobin is responsible for carrying oxygen to cells throughout the body.
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A novel model of COVID-19 Pathogenesis and Treatment

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As the COVID-19 pandemic progresses, the need to develop new vaccines and therapeutics intensifies. Animal models of infection play important roles in such discoveries, with mice being the most widely
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A novel model of apoE4 toxicity in Alzheimer’s disease

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Alzheimer’s disease (AD) is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of an aging world population. This neurodegenerative disease is characte
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Microbial Infection Induces Autoimmunity

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Dr. Julie Blander’s group at the School of Medicine at Mount Sinai have discovered that during an infection that causes the apoptosis of infected cells, CD4+ T cells with specificity to self-antigens
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Anti-CD47 antibodies counter cardiovascular disease

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Nicholas J. Leeper’s group at the Stanford University School of Medicine have discovered that the signal that tumor cells display on their surfaces to protect themselves from being cleared by the immu
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LIGHT-HVEM signaling protects against enteric bacterial infection

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It is known that ILCs in the small intestine play a protective role against several mucosal bacterial infections including Yersinia enterocolitica (YE) infection.
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CD40 stimulation drives T cell immunity in cancer

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Drs. Katelyn Byrne and Robert Vonderheide from the University of Pennsylvania have discovered that CD40 stimulation along with chemotherapy causes T cell-dependent destruction of pancreatic ductal ade
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