Breast cancer deaths are often the result of metastasis to distant organs including the lungs. Overcoming inhibitory mechanisms and establishing growth in new microenvironments is critical to the metastatic process. Using anti-mouse IL-1b (clone B122) and anti-mouse IL-6 (clone MP5-20F3) antibodies from Bio X Cell, researchers have described a role for the tumor-secreted protease, cathepsin C (CTSC) in helping breast cancer cells use neutrophils to colonize the lungs.
Read More
The ability of tumor cells to evade immune detection plays a critical role in tumor development. Utilizing Bio X Cell’s anti-mouse PD-1 (clone J43) antibody, researchers discovered that expression of the intergenic long noncoding RNA (lincRNA) EPIC1 helps cancer cells escape recognition by the immune system.
Read More
Although immune checkpoint inhibitors have changed the treatment landscape for some cancers such as melanoma and non-small cell lung cancer, other tumor types often described as immunologically “cold” do not respond well to immunotherapy. Using Bio X Cell’s Anti-mouse RANKL (clone IK22/5) antibody, researchers demonstrated that inhibition of the RANK pathway turns cold breast tumors into hot tumors that can potentially benefit from immunotherapy.
Read More
Why do certain people become sick after exposure to a virus while others do not? Bio X Cell’s anti-mouse Ly6G (clone 1A8) and anti-mouse CD8 (clone YTS169.4) antibodies were used to help define neutrophilic inflammation as an important component of susceptibility to respiratory infections.
Read More
More than 10,000 liters of non-sterile air pass through our lungs each day. Although most pathogens are filtered out in the upper respiratory tract, evidence suggests that some bacteria make their way into the alveoli where oxygen and carbon dioxide are exchanged in the lungs.
Read More
Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in the hemoglobin gene. Hemoglobin is responsible for carrying oxygen to cells throughout the body.
Read More
As the COVID-19 pandemic progresses, the need to develop new vaccines and therapeutics intensifies. Animal models of infection play important roles in such discoveries, with mice being the most widely
Read More
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, with the prevalence continuing to grow in part because of an aging world population. This neurodegenerative disease is characte
Read More
Dr. Julie Blander’s group at the School of Medicine at Mount Sinai have discovered that during an infection that causes the apoptosis of infected cells, CD4+ T cells with specificity to self-antigens
Read More
Nicholas J. Leeper’s group at the Stanford University School of Medicine have discovered that the signal that tumor cells display on their surfaces to protect themselves from being cleared by the immu
Read More