Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

Posted in Research Highlights

  AUTHORS Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G. Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato, Fernando Aranda, Sylvère Durand, Alexandre Boissonnas, Jitka Fucikova, Laura ...
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IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

Posted in Research Highlights

    AUTHORS Shao-Wei Lu, Hong-Chin Pan, Yu-Hsiang Hsu, Kung-Chao Chang, Li-Wha Wu, Wei-Yu Chen & Ming-Shi Chang   SUMMARY Pancreatic ductal adenocarcinoma (PDAC) and cancer-associated cachexia (CAC) are multifactorial and characterized by dysregulate...
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Team-Building Adventure: Upper Valley Land Trust Group Volunteering

Posted in Community

    On Wednesday, September 23, 2020 members of the Bio X Cell team participated in the Corporate Volunteer Program of the Upper Valley Land Trust (UVLT). Participants met with UVLT staffers Paul and Kaytee at the Lyme Hill Conservation Area where th...
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𝘐𝘯𝘝𝘪𝘷𝘰MAb anti-mouse NKG2AB6 (Clone 16A11)

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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

Posted in Research Highlights

  AUTHORS Angela C. Crespo, Sachin Mulik, Farokh Dotiwala, James A. Ansara, Sumit Sen Santara, Kayleigh Ingersoll, Cristian Ovies, Caroline Junqueira, Tamara Tilburgs, Jack L. Strominge, Judy Lieberman   SUMMARY Maternal decidual NK (dNK) cells promo...
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Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection

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The Bio X Cell Fund Supports Disaster Relief

Posted in Bio X Cell Charitable Fund

  Each fiscal year, the Bio X Cell Charitable Fund earmarks a portion of its budget for disaster relief. In 2020, the Bio X Cell Fund Committee voted to support four organization which are facilitating recovery and rebuilding efforts in the ongoing w...
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IκBα Nuclear Export Enables 4-1BB–Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity

Posted in Research Highlights

  AUTHORS  Dominique N. Lisiero, Zhang Cheng, Melba M. Tejera, Brandon T. Neldner, Jay W. Warrick, Shelly M. Wuerzberger-Davis, Alexander Hoffmann, M. Suresh and Shigeki Miyamoto   SUMMARY Optimal CD8 T cell immunity is orchestrated by signaling even...
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𝙄𝙣𝙑𝙞𝙫𝙤MAb anti-human CD220 / Insulin Receptor (Clone IR 83-22)

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The Gut Microbiome Links Stress to Sickle Cell Crisis

Posted in Research Highlights

  Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in the hemoglobin gene. Hemoglobin is responsible for carrying oxygen to cells throughout the body. Mutations in the hemoglobin gene results in red blood cells with a c...
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