The ability of tumor cells to evade immune detection plays a critical role in tumor development. Utilizing Bio X Cell’s anti-mouse PD-1 (clone J43) antibody, researchers discovered that expression of the intergenic long noncoding RNA (lincRNA) EPIC1 helps cancer cells escape recognition by the immune system.
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January 31 - February 6, 2021 is the Lab Animal Technician Week! Bio X Cell celebrated with Champions Oncology this year, to honor these essential employees working tirelessly through the COVID outbreak, so important research can continue.
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Although immune checkpoint inhibitors have changed the treatment landscape for some cancers such as melanoma and non-small cell lung cancer, other tumor types often described as immunologically “cold” do not respond well to immunotherapy. Using Bio X Cell’s Anti-mouse RANKL (clone IK22/5) antibody, researchers demonstrated that inhibition of the RANK pathway turns cold breast tumors into hot tumors that can potentially benefit from immunotherapy.
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Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Bio X Cell antibodies are used to study type I IFN exacerbates disease in tuberculosis susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
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Every child deserves to experience the joy of the holidays. In the spirit of giving this season, members of the Bio X Cell team purchased gifts for Toys for Tots and collected them under the Christmas tree decorating our headquarters.
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Why do certain people become sick after exposure to a virus while others do not? Bio X Cell’s anti-mouse Ly6G (clone 1A8) and anti-mouse CD8 (clone YTS169.4) antibodies were used to help define neutrophilic inflammation as an important component of susceptibility to respiratory infections.
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Corky’s art show at Bio X Cell demonstrates a wide range of colors and styles. Pieces in the exhibit range from cool-toned abstracts to canvases bursting with red and gold, to more figurative paintings. Her work hovers between contemporary and timeless and is a joy to contemplate.
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