Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

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  AUTHORS Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G. Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato, Fernando Aranda, Sylvère Durand, Alexandre Boissonnas, Jitka Fucikova, Laura ...
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IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

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    AUTHORS Shao-Wei Lu, Hong-Chin Pan, Yu-Hsiang Hsu, Kung-Chao Chang, Li-Wha Wu, Wei-Yu Chen & Ming-Shi Chang   SUMMARY Pancreatic ductal adenocarcinoma (PDAC) and cancer-associated cachexia (CAC) are multifactorial and characterized by dysregulate...
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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

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  AUTHORS Angela C. Crespo, Sachin Mulik, Farokh Dotiwala, James A. Ansara, Sumit Sen Santara, Kayleigh Ingersoll, Cristian Ovies, Caroline Junqueira, Tamara Tilburgs, Jack L. Strominge, Judy Lieberman   SUMMARY Maternal decidual NK (dNK) cells promo...
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Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection

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IκBα Nuclear Export Enables 4-1BB–Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity

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  AUTHORS  Dominique N. Lisiero, Zhang Cheng, Melba M. Tejera, Brandon T. Neldner, Jay W. Warrick, Shelly M. Wuerzberger-Davis, Alexander Hoffmann, M. Suresh and Shigeki Miyamoto   SUMMARY Optimal CD8 T cell immunity is orchestrated by signaling even...
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The Gut Microbiome Links Stress to Sickle Cell Crisis

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  Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in the hemoglobin gene. Hemoglobin is responsible for carrying oxygen to cells throughout the body. Mutations in the hemoglobin gene results in red blood cells with a c...
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Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

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AUTHORS  Wenjing Yang, Tianming Yu, Xiangsheng Huang, Anthony J. Bilotta, Leiqi Xu, Yao Lu, Jiaren Sun, Fan Pan, Jia Zhou, Wenbo Zhang, Suxia Yao, Craig L. Maynard, Nagendra Singh, Sara M. Dann, Zhanju Liu & Yingzi Cong   SUMMARY Innate lymphoid cell...
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Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD

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  AUTHORS  Bradley W. Richmond, Samira Mansouri, Ana Serezani, Sergey Novitskiy, Jessica B. Blackburn, Rui-Hong Du, Hubaida Fuseini, Sergey Gutor, Wei Han, Jacob Schaff, Georgii Vasiukov, Matthew K. Xin, Dawn C. Newcomb, Lei Jin, Timothy S. Blackwell...
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Enhancing mucosal immunity by transient microbiota depletion

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Enhancing mucosal immunity by transient microbiota depletion           Authors: Simone Becattini, Eric R. Littmann, Ruth Seok, Luigi Amoretti, Emily Fontana, Roberta Wright, Mergim Gjonbalaj, Ingrid M. Leiner, George Plitas, Tobias M. Hohl & Eric G. ...
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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses

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Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8+ T cell responses           Authors: Seon-Hee Kim, Rohit Singh, Chungyong Han, Eunjung Cho, Yu I. Kim, Don G. Lee,...
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