𝙄𝙣𝙑𝙞𝙫𝙤MAb anti-human/monkey MDR-1 (CD243) (Clone UIC2)

The UIC2 monoclonal antibody reacts with an extracellular epitope of human and monkey (African Green) multidrug resistance protein 1 (MDR-1) also known as CD243, P-glycoprotein, and ABCB1. MDR-1 is a 170-180 kDa transmembrane glycoprotein that is expressed by epithelial and endothelial cells, and at low levels by T cells, B cells, NK cells, and hematopoietic stem cells. It is thought to be expressed at high levels by multidrug resistant (MDR) tumor cells. MDR-1 is as an ATP-dependent efflux pump for a large variety of molecules and drugs. This efflux activity has been suggested to lead to resistance to chemotherapy drugs. The UIC2 antibody has been reported to inhibit the efflux of MDR-1 substrates from MDR cells and increase the cytotoxicity of certain drugs in xenogeneic murine tumor models. The UIC2 antibody does not cross-react with mouse MDR-1.
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STAT5 promotes accessibility and is required for BATF-mediated plasticity at the Il9 locus

Posted in Research Highlights

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Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer

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IL-20 antagonist suppresses PD-L1 expression and prolongs survival in pancreatic cancer models

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Team-Building Adventure: Upper Valley Land Trust Group Volunteering

Posted in Community

It was a beautiful afternoon combining a team-building activity with service. Participants left feeling good about giving back to our community while, at the same time, having fun and enjoying a safe and beautiful afternoon outdoors. We look forward to holding similar events in the future.
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𝘐𝘯𝘝𝘪𝘷𝘰MAb anti-mouse NKG2AB6 (Clone 16A11)

Posted in New Products

Introducing 𝘐𝘯𝘝𝘪𝘷𝘰MAb anti-mouse NKG2AB6 Clone 16A11 for western blot applications.
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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

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Type I IFNs and CD8 T cells increase intestinal barrier permeability after chronic viral infection

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The Bio X Cell Fund Supports Disaster Relief

Posted in Bio X Cell Charitable Fund

The Bio X Cell Fund is proud to support these organizations and the work they are doing to help rebuild and recover from natural disasters.
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IκBα Nuclear Export Enables 4-1BB–Induced cRel Activation and IL-2 Production to Promote CD8 T Cell Immunity

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