Naïve T cells switch to one-carbon metabolism upon activation
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Marcia C. Haigis’s group from the Department of Cell Biology at Harvard Medical School have discovered that CD4 T cell activation requires a unique program of mitochondrial biogenesisis.
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Microbiota-derived short-chain fatty acids promote Th1 cell IL-10 production to maintain intestinal homeostasis
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The gut microbiota has been shown to play important roles in maintaining intestinal homeostasis.
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The program for central memory T cell generation is preserved intrinsically in CD8 T cells.
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Eun Young Choi’s group from the Seoul National University College of Medicine have discovered that CD4 T cell help is not required to initiate differentiation of CD8 T cells into central memory T cell
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TIGIT blockade prevents NK cell exhaustion and elicits potent anti-tumor immunity
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TIGIT deficiency in NK cells is sufficient to delay tumor growth in vivo and blockade of TIGIT via monoclonal antibodies reverses the exhaustion of anti-tumor NK cells in multiple tumor models and imp
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Regulatory T cells use lymphotoxin beta receptor to migrate from tissues to lymph nodes
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Dr. Jonathan S. Bromberg’s group from the University of Maryland School of Medicine have discovered that Tregs preferentially express and use lymphotoxin αβ for migration to lymph nodes.
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