Bio X Cell Conference Travel Award at EMIM

Posted in Community

At Bio X Cell, we are always looking for opportunities to support our scientists and their exciting research. This year, we supported our travel grant applicant, Julia Hoebart, on her travel expenses to attend the European Molecular Imaging Meeting (EMIM) in Goettingen, Germany. She presented results from her PhD project that used anti-mouse PD-L1 antibody (clone 10F.9G2) from Bio X Cell as a targeting moiety for radiotracer for preclinical imaging studies. Congratulations to Julia for receiving a presentation award for her scientific elevator pitch!
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Preventing Breast Cancer Metastasis: A Role for Cathepsin C Inhibitors

Posted in Research Summary

Breast cancer deaths are often the result of metastasis to distant organs including the lungs. Overcoming inhibitory mechanisms and establishing growth in new microenvironments is critical to the metastatic process. Using anti-mouse IL-1b (clone B122) and anti-mouse IL-6 (clone MP5-20F3) antibodies from Bio X Cell, researchers have described a role for the tumor-secreted protease, cathepsin C (CTSC) in helping breast cancer cells use neutrophils to colonize the lungs.
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LincRNA EPIC1 Mediates Immunotherapy Resistance

Posted in Research Summary

The ability of tumor cells to evade immune detection plays a critical role in tumor development. Utilizing Bio X Cell’s anti-mouse PD-1 (clone J43) antibody, researchers discovered that expression of the intergenic long noncoding RNA (lincRNA) EPIC1 helps cancer cells escape recognition by the immune system.
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Happy Lab Animal Technician Week!

Posted in Community, Bio X Cell Charitable Fund

January 31 - February 6, 2021 is the Lab Animal Technician Week! Bio X Cell celebrated with Champions Oncology this year, to honor these essential employees working tirelessly through the COVID outbreak, so important research can continue.
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Turning Cold Tumors Hot: The RANK Pathway as an Immune Modulator in Breast Cancer

Posted in Research Summary

Although immune checkpoint inhibitors have changed the treatment landscape for some cancers such as melanoma and non-small cell lung cancer, other tumor types often described as immunologically “cold” do not respond well to immunotherapy. Using Bio X Cell’s Anti-mouse RANKL (clone IK22/5) antibody, researchers demonstrated that inhibition of the RANK pathway turns cold breast tumors into hot tumors that can potentially benefit from immunotherapy.
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Type I IFN Exacerbates Disease in Tuberculosis Susceptible Mice by Inducing Neutrophil-mediated Lung Inflammation and NETosis

Posted in Research Highlights

Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Bio X Cell antibodies are used to study type I IFN exacerbates disease in tuberculosis susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.
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Gifts Under the Christmas Tree

Posted in Community, Bio X Cell Charitable Fund

Every child deserves to experience the joy of the holidays. In the spirit of giving this season, members of the Bio X Cell team purchased gifts for Toys for Tots and collected them under the Christmas tree decorating our headquarters.
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Mucosal Microenvironment Matters: A Role for Neutrophilic Inflammation in Viral Predisposition

Posted in Research Summary

Why do certain people become sick after exposure to a virus while others do not? Bio X Cell’s anti-mouse Ly6G (clone 1A8) and anti-mouse CD8 (clone YTS169.4) antibodies were used to help define neutrophilic inflammation as an important component of susceptibility to respiratory infections.
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Corky's Art Exhibit at Bio X Cell

Posted in Community

Corky’s art show at Bio X Cell demonstrates a wide range of colors and styles. Pieces in the exhibit range from cool-toned abstracts to canvases bursting with red and gold, to more figurative paintings. Her work hovers between contemporary and timeless and is a joy to contemplate.
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Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s

Posted in Research Highlights

Bio X Cell Reference Spotlight
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