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The UIC2 monoclonal antibody reacts with an extracellular epitope of human and monkey (African Green) multidrug resistance protein 1 (MDR-1) also known as CD243, P-glycoprotein, and ABCB1. MDR-1 is a 170-180 kDa transmembrane glycoprotein that is expressed by epithelial and endothelial cells, and at low levels by T cells, B cells, NK cells, and hematopoietic stem cells. It is thought to be expressed at high levels by multidrug resistant (MDR) tumor cells. MDR-1 is as an ATP-dependent efflux pump for a large variety of molecules and drugs. This efflux activity has been suggested to lead to resistance to chemotherapy drugs. The UIC2 antibody has been reported to inhibit the efflux of MDR-1 substrates from MDR cells and increase the cytotoxicity of certain drugs in xenogeneic murine tumor models. The UIC2 antibody does not cross-react with mouse MDR-1.
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This antibody is useful for:
in vivo MDR-1 blocking/depletion in xenogeneic murine
tumor models
in vitro MDR-1 blocking
Immunohistochemistry (paraffin)
Bio X Cell antibodies are specifically formulated for in vivo use and feature:
95% purity
Ultra-low endotoxin levels
Preservative, stabilizer, and carrier protein-free
Recommended isotype control and dilution buffer:
InVivoMAb mouse IgG2a isotype control, unknown specificity
InVivoPure pH 7.0 Dilution Buffer