InVivoMAb anti-mouse/human/rat LRP1 (CD91)
The 11H4 monoclonal antibody reacts with mouse, human, and rat low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) and CD91. LRP1 is synthesized as a signal polypeptide chain that undergoes cleavage, shortly after synthesis, into the 85 kDa transmembrane β chain that non-covalently binds to the extracellular 500-515 kDa α chain. The 11H4 antibody binds to the β chain of LRP1. LRP1 is an endocytic receptor involved with intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. Additionally, LRP1 is the primary receptor mediating transport of amyloid beta (Aβ) peptides across the blood-brain barrier into circulation, thereby clearing them from the brain. Dysfunction of LRP1 may be a contributing factor in the development of Alzheimer’s disease.
This Antibody Is Useful For:
As always Bio X Cell antibodies are specifically formulated for in vivo use and feature:
Ultra-low endotoxin levels
Preservative, stabilizer, and carrier protein-free
Recommended Control and Buffer:
InVivoMAb mouse IgG1 isotype control, unknown specificity
The MOPC-21 monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications.
InVivoPure pH 7.0 Dilution Buffer
InVivoPure™ dilution buffers are specifically formulated and tested to satisfy the stringent requirements for in vivo applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cell’s antibodies.