InVivoMAb anti-mouse CD69
The CD69.2.2 monoclonal antibody reacts with mouse CD69, an 85 kDa type II C-type lectin. CD69 expression is rapidly induced upon cell activation in all leukocytes. CD69 is thought to be a negative regulator of the immune response in part through modulating the production of TGF-β. Studies in CD69-deficient mice have revealed that CD69 plays crucial roles in the pathogenesis of various inflammatory diseases including arthritis, asthma, and colitis. When administered in vivo the CD69.2.2 antibody causes CD69 to be internalized but does not deplete CD69+ cells. Anti-CD69-treated mice resemble CD69-/- mice to a remarkable degree. The CD69.2.2 antibody has been shown to activate NK cells in vivo and in vitro and promote anti-tumor responses.
This Antibody Is Useful For:
- in vivo down-regulation of CD69 expression
- Functional assays
As always Bio X Cell antibodies are specifically formulated for in vivo use and feature:
- 95% purity
- Ultra-low endotoxin levels
- Preservative, stabilizer, and carrier protein-free
Recommended Control and Buffer:
InVivoMAb mouse IgG1 isotype control, unknown specificity
The MOPC-21 monoclonal antibody is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications.
InVivoPure pH 7.0 Dilution Buffer
InVivoPure™ dilution buffers are specifically formulated and tested to satisfy the stringent requirements for in vivo applications. They are extremely low in endotoxin, have been screened for murine pathogens, tested in animal models for toxicity and are formulated with respect to buffer composition and pH to satisfy the requirements of Bio X Cell’s antibodies.